Look beyond limits




The reality of retinal disease

Retinal disease is a significant public health issue that is now affecting more of us than ever before. The number of people living with two of the leading causes of vision loss - Neovascular Age-related Macular Degeneration (nAMD) and Diabetic Macular Edema (DME) - worldwide is set to grow,1–8 further increasing the pressure on health system capacity.

Projected number of people living with retinal disease1-6


These diseases can have a devastating impact upon our work, our health systems, and those we care about most by closing the window to independence. 

People may struggle to:9–13


Current therapy limitations

Anti-VEGF IVT treatments have been shown to improve vision for many people with retinal vascular disease. However, those benefits are difficult to achieve and maintain in the real world without frequent injections.16-19

Frequent IVT injections place a significant burden on peoples’ lives:20–22


22-57% of people with nAMD stop anti-VEGF IVT treatment over 5 years in real-world studies (common reasons include distance to hospital and number of visits)23-25

Vision outcomes deteriorate over time despite injections every 2-3 months:14,19


Real-world studies in DME and nAMD found that average vision gains worsened between 2 and 5 years of anti-VEGF treatment, despite people receiving 4-5 injections annually

Other disease pathways may lead to long-term detrimental effects on vision:26-28


Inhibiting VEGF alone does not address the inflammatory response associated with the progression of nAMD and DME28

Continuous dosing may offer an alternative solution:29


The majority of nAMD patients who received continuous fixed-interval dosing of anti-VEGF experienced stabilisation or even improvement of their vision29

It’s time for a new approach

Treatments with new modes of action and better delivery mechanisms are needed to address the multifactorial nature of retinal disease, to help patients achieve longer‑term vision gains and reduce the burden of treatment.

Step into the future of ophthalmology 

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